2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel
  5. Sodium Channel Modulator

Sodium Channel Modulator

Sodium Channel Isoform Comparison

Sodium Channel Modulators (19):

Cat. No. Product Name Effect Purity
  • HY-P1604A
    ATX-II TFA
    		Modulator 99.84%
    ATX-II TFA is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na+
  • HY-19666
    DPI 201-106
    		Modulator 99.49%
    DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect.
  • HY-P5159A
    Crotamine TFA
    		Modulator 98.06%
    Crotamine TFA is a Na+ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom.
  • HY-P4898A
    Anthopleurin-A TFA
    		Modulator 98.39%
    Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone.
  • HY-13412
    Cariporide (mesilate)
    		Modulator
    Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1.
  • HY-P5159
    Crotamine
    		Modulator
    Crotamine is a Na+ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom.
  • HY-P10234
    Poneratoxin
    		Modulator
    Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain.
  • HY-116436
    Clathrodin
    		Modulator
    Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance.
  • HY-P4898
    Anthopleurin-A
    		Modulator
    Anthopleurin-A is a soidum channel toxin. Anthopleurin-A is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A can be isolated from the sea anemone.
  • HY-162757
    Anticonvulsant agent 5
    		Modulator
    Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABAA receptors and NaV1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED50 of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid (HY-N2309) with an IC50 of 113 μM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable.
  • HY-100939
    4-Chlorophenylguanidine hydrochloride
    		Modulator 99.07%
    4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo.
  • HY-P1604
    ATX-II
    		Modulator
    ATX-II is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na+
  • HY-P5869
    Kurtoxin
    		Modulator
    Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor with a Kd of 15 nM for Cav3.1 (α1G T-type) Ca2+ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca2+ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na+ channel.
  • HY-P1443
    OD1
    		Modulator
    OD1 is a scorpion α-toxin that can be isolated from the venom of the Iranian yellow scorpion (Odonthobuthus doriae. OD1 is a modulator of mammalian Nav1.7 (EC50: 4.5 nM).
  • HY-P5786
    Heteropodatoxin-1
    		Modulator
    Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8.
  • HY-P5144
    Aah II
    		Modulator
    Aah II is a sodium channel modulator. Aah II is a toxin that can be isolated from the venom of scorpion Androctonus australis.
  • HY-123833
    PF-05661014
    		Modulator
    PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation.
  • HY-129258
    Lycoctonine
    		Modulator
    Lycoctonine is a diterpene alkaloid. Lycoctonine interacts the sodium channel, affects the heart and central nervous system, exhibits analgesic, anti-inflammatory, anti-epileptic and cardiovascular activities.
  • HY-P0268
    Myomodulin
    		Modulator
    Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.